The Commercial-News, Danville, IL

Community News Network

October 18, 2013

Sleep: The ultimate brainwasher?

(Continued)

In the original work, Nedergaard's group showed that glia, the brain's non-neuronal cells, control the flow of CSF through channels in their cell membranes. "If we delete the channels in glial cells, the flow almost stops," Nedergaard says. Because the transport of fluid across cell membranes requires a lot of energy, Nedergaard and her team had a hunch that the brain would not be able to both clean and process sensory information at the same time and decided to test whether the activity of the glymphatic system changed during sleep. Lulu Xie, the new study's first author, spent the next 2 years training mice to relax and fall asleep on a two-photon microscope, which can image the movement of dye through living tissue.

Once Xie was sure the mice were asleep, based on their EEG brain activity, she injected a green dye into their CSF through a catheterlike device in their necks. After half an hour, she awakened them by touching their tails and injected a red dye that the two-photon microscope could easily distinguish from the green. By tracking the movements of red and green dye throughout the brain, the team found that large amounts of CSF flowed into the brain during sleep, but not during the awake state, Nedergaard says.

A comparison of the volume of space between nerve cells while the mice were awake and asleep revealed that the glial channels carrying CSF expanded by 60 percent when the mice were asleep. The team also injected labeled β amyloid proteins into the brains of sleeping mice and awake mice and found that during sleep, CSF cleared away this "dirt" outside of the cells twice as quickly — "like a dishwasher," Nedergaard says. Such proteins can aggregate as pathogenic plaques inside cells and are associated with Alzheimer's disease, she says.

Text Only
Community News Network
E-edition
AP Video
Renewed Violence Taking Toll on Gaza Residents 2 Americans Detained in North Korea Seek Help US Employers Add 209K Jobs, Rate 6.2 Pct House GOP Optimistic About New Border Bill Gaza Truce Unravels; Israel, Hamas Trade Blame Raw: Tunisia Closes Borders With Libya Four Rescued From Crashed Plane Couple Channel Grief Into Soldiers' Retreat WWI Aviation Still Alive at Aerodrome in NY Raw: Rescuers at Taiwan Explosion Scene Raw: Woman Who Faced Death Over Faith in N.H. Clinton Before 9-11: Could Have Killed Bin Laden Netanyahu Vows to Destroy Hamas Tunnels Obama Slams Republicans Over Lawsuit House Leaders Trade Blame for Inaction
NDN Video
Under Armour Launches Biggest Women's Campaign with Inspiring Ad NYPD chokehold death of Eric Garner was homicide: medical examiner Christina Aguilera Pulls a Demi Moore! Man with no arms throws first pitch Chapter Two: Composing for a film in retirement Is Justin Bieber Dating a Model? Guardians of the Galaxy (Trailer) 'Sharknado 2:' Hottest Memes Surfing The Net Snoop Dogg Narrating Animal Footage Is Perfect Raw: Obama Gets Hug From Special Olympian Recapping a Blockbuster MLB Trade Deadline Tigers Acquire David Price - @TheBuzzeronFOX Russell Brand Slams Sean Hannity Over Gaza Conflict Segment Woman's Dive Goes Terribly Wrong Brian Williams Reports on Daughter Allison Williams' 'Peter Pan' Casting News Did Jimmy Fallon Look Up Heidi Klum's Dress? What Drama? Miranda Kerr Poses Topless Plane crashes in San Diego Costco parking lot Justin Bieber Takes To Instagram To Diss Orlando Bloom You Won't Believe the Celeb Cameos in "Sharknado 2"
Must Read